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Nanotechnology in Health Care
Market Report, February 2007, 3600  €


Description

This study analyzes the emerging US market for nanotechnology medical products, which are defined as pharmaceuticals, diagnostics, and medical supplies and devices based on compounds or structures of 1,000 nanometers or less in size.
The content presented in the last version of this study (published in May 2005) has been expanded and updated to include drugs and diagnostics composed of monoclonal antibodies and diagnostics based on biochips (microarrays).
Although not widely publicized as such, both monoclonal antibodies and biochips meet the above definition for nanomaterials.

Sommaire
 
INTRODUCTION xii

I. EXECUTIVE SUMMARY 1

II. MARKET ENVIRONMENT 4
General 4
Macroeconomic Outlook 5
Demographic Trends 7
Health Care Trends 9
Medical Conditions 10
Chronic Conditions 12
Acute Conditions 16
Health Insurance & Reimbursement 17
National Health Expenditures 19
Medical Providers 24
Hospitals 25
Outpatient Facilities 25
Physicians 26
Dentists 26
Other Health Care Providers 26
Patient Activity 27
Surgical Procedures 28
Outpatient Visits 29
Diagnostic Tests 30
Medical Product Demand 31
Pharmaceuticals 32
Diagnostic Products 36
In Vitro Diagnostic (IVD) Products 37
In Vivo Imaging Agents 38
Medical Supplies & Devices 40

III. NANOTECHNOLOGY OVERVIEW 44
General 44
Product Groups 47
Regulatory Trends 48
Pharmaceuticals 49
Diagnostic Products 50
Medical Supplies & Devices 51
Current Good Manufacturing Practices (cGMPs) 52
Investment Environment 53
International Markets 55

IV. NANOMATERIALS 59
General 59
Monoclonal Antibodies 60
DNA Materials 61
Nanoparticles 64
Nanotubes & Nanowires 66
Dendrimers 67
Fullerenes 68
Quantum Dots 68
Other Nanomaterials 70

V. NANOMEDICINES 71
General 71
Product Groups 74
Monoclonal Antibodies 76
Marketed Products 77
Products in Development 93
Polymer-Based Nanomedicines 95
Marketed Products 96
Developmental Activities 102
Other Nanomedicines 112
Nanocrystal Therapies 113
Liposomes 116
Marketed Products 117
Products in Development 119
All Other Nanomedicines 121
Marketed Products 122
Products in Development 125

VI. NANODIAGNOSTICS 141
General 141
In Vitro Diagnostics 143
Monoclonal Antibodies 144
Immunological Reagents & Test Kits 146
Immunohematology 152
Cellular Analysis 154
Research Reagents 156
DNA Testing Materials 157
Amplified DNA Probes 158
Direct DNA Probes 161
DNA Microarrays 163
Other DNA Testing Materials 167
In Vivo Diagnostics 178
MRI Imaging Agents 179
Advanced Magnetics 181
Kereos 182
Other Development Stage Compounds 182
Other Diagnostic Imaging Agents 184

VII. NANOTECH MEDICAL SUPPLIES & DEVICES 187
General 187
Orthopedic Products 189
Bone Cement 190
Bone Substitutes 191
Orthopedic Implants 194
Wound Management Products 198
Wound Closures 199
Wound Dressings 201
Dental Products 203
Surgical Products 206
Ophthalmic Products 208
Other Nanotechnology Medical Supplies & Devices 211
Disinfectants 212
Cardiac Implants 214
Cochlear Implants 215
Catheters 216
Neuron Regenerators 216
Artificial Skin 218

VIII. APPLICATIONS 220
General 220
Cancer 223
Epidemiological Trends 224
Nanomedicines 225
Diagnostics 227
Central Nervous System Conditions 229
Epidemiological Trends 230
Nanomedicines 231
Diagnostics 233
Medical Supplies & Devices 233
Infective & Parasitic Conditions 234
Epidemiological Trends 236
Nanomedicines 236
Diagnostics 238
Cardiovascular Conditions 239
Epidemiological Trends 240
Nanomedicines 241
Diagnostics 242
Medical Supplies & Devices 244
Other Applications 244

IX. INDUSTRY STRUCTURE 251
General 251
Market Share 252
Competitive Strategies 254
Licensing Agreements 256
Research & Development 260
Marketing & Distribution 263
Manufacturing 264
Company Profiles 265
Abbott Laboratories 266
Abraxis BioScience Incorporated 268
Access Pharmaceuticals Incorporated 270
Advanced Magnetics Incorporated 271
Advion BioSciences Limited 272
Alnis BioSciences Incorporated 273
Altair Nanotechnologies Incorporated 273
ALZA Corporation, see Johnson & Johnson
American BioScience, see Abraxis BioScience
American Pharmaceutical Partners, see Abraxis BioScience
Amgen Incorporated 274
Angstrom Medica Incorporated 276
Arrowhead Research Corporation 277
AstraZeneca plc 278
Avidimer Therapeutics Incorporated 279
Baxter International Incorporated 280
Bayer AG 281
BioDelivery Sciences International 282
BioForce Nanosciences Holdings Incorporated 283
Biogen Idec Incorporated 284
Biophan Technologies Incorporated 285
BioSante Pharmaceuticals Incorporated 286
BioTrove Incorporated 287
Bristol-Myers Squibb Company 287
C Sixty, see Carbon Nanotechnologies
Carbon Nanotechnologies Incorporated 289
CritiTech Incorporated 290
Crystalplex Corporation 291
CytImmune Sciences Incorporated 291
Danaher Corporation 292
Dendritic NanoTechnologies, see Starpharma Holdings
Dow Chemical Company 293
Elan Corporation plc 295
Enzon Pharmaceuticals Incorporated 299
eSpin Technologies Incorporated 300
Ferro Corporation 301
Flamel Technologies SA 302
GeneFluidics Incorporated 304
Genentech Incorporated 304
Health Plus International Incorporated 307
Improvita Health Products Incorporated 308
Insert Therapeutics, see Arrowhead Research
International Business Machines Corporation 309
Intradigm Corporation 309
Introgen Therapeutics Incorporated 310
Invitrogen Corporation 311
Johnson & Johnson 312
Kerr Corporation, see Danaher Corporation
Lavipharm Corporation 315
Luna Innovations Incorporated 315
Mallinckrodt, see Tyco International
Merck & Company Incorporated 316
Mersana Therapeutics Incorporated 317
NanoBio Corporation 318
NanoBioMagnetics Incorporated 319
NanoBioTec GmbH 319
Nanobiotix SA 320
NanoCarrier Company Limited 320
NanoCure Corporation, see Avidimer Therapeutics
NanoDel Technologies GmbH 321
Nanodisc Incorporated 322
Nanogen Incorporated 322
NanoHorizons Incorporated 323
NanoInk Incorporated 324
NanoLab 324
NanoMaterials Technology Pte Limited 325
NanoMed Pharmaceuticals Incorporated 326
Nanomix Incorporated 327
Nanopharma Corporation, see Mersana Therapeutics
Nanoplex Technologies, see Oxonica Limited
Nanospectra Biosciences Incorporated 327
Nanosys Incorporated 328
Nektar Therapeutics 329
Novagali Pharma SA 331
Novavax Incorporated 331
NUCRYST Pharmaceuticals Corporation 332
Ortho Biotech Products, see Johnson & Johnson
Orthovita Incorporated 334
Oxonica Limited 335
Pfizer Incorporated 336
PharmaSol GmbH 337
pSivida Limited 338
Quantum Dot, see Invitrogen Corporation
Roche Holding Limited 339
Salvona LLC 340
Sensatex Incorporated 341
Siemens AG 342
SkyePharma plc 342
Smiths Group plc 343
Soliqs, see Abbott Laboratories
Spire Corporation 344
Starpharma Holdings Limited 344
Sybron Dental Specialties, see Danaher
Tailored Materials Corporation Incorporated 345
Teva Pharmaceutical Industries Limited 346
3M Company 347
Triton BioSystems Incorporated 347
Tyco International Limited 348
Wyeth 349

LIST OF TABLES
TABLE NUMBER PAGE
SECTION I -- EXECUTIVE SUMMARY
Summary Table 3

SECTION II -- MARKET ENVIRONMENT
1 Macroeconomic Indicators 7
2 Population by Age Group 8
3 Medical Conditions by Duration & Type 12
4 National Health Expenditures by Type 23
5 Selected Medical Providers by Type 24
6 Selected Patient Activity by Type 28
7 Medical Product Demand by Type 32
8 Pharmaceutical Demand by Therapeutic Class 35
9 Diagnostic Product Demand by Type 37

SECTION III -- NANOTECHNOLOGY OVERVIEW
1 Nanotechnology Medical Product Demand by Type 46
2 R&D Investment in Nanotechnology Medical Products 55

SECTION V -- NANOMEDICINES
1 Nanomedicine Demand by Therapeutic Class 73
2 Nanomedicine Demand by Product Group 75
3 Therapeutic Monoclonal Antibody Demand 77
4 Therapeutic Monoclonal Antibodies Approved for US Sale 79
5 Therapeutic Monoclonal Antibodies -- US Sales by Product,
2001 & 2006 91
6 Polymer-Based Nanomedicine Demand 95
7 Polymer-Based Nanomedicines Approved for US Sale 96
8 Polymer-Based Nanomedicines -- US Sales by Product,
2001 & 2006 101
9 Other Nanomedicine Demand 113
10 Nanocrystal Medicines Approved for US Sale 116
11 Liposomal Therapies Approved for US Sale 117
12 Other Nanomedicines Approved for US Sale 122

SECTION VI -- NANODIAGNOSTICS
1 Nanotechnology-Based Diagnostic Product Demand
by Segment 142
2 Nanotechnology In Vitro Diagnostic Product Demand
by Type 144

(continued on next page) 3 Monoclonal Antibody-Based Diagnostic Product Demand
by Type 146
4 Monoclonal Antibody-Based Immunological Reagent & Test
Kit Demand 147
5 Monoclonal Antibody-Based Immunohematology Reagent
& Test Kit Demand 154
6 Monoclonal Antibody-Based Cellular Analysis Reagent
& Test Kit Demand 156
7 Monoclonal Antibody-Based Research Reagent Demand 157
8 DNA Testing Material Demand by Type 158
9 Amplified DNA Probe Demand 161
10 Direct DNA Probe Demand 162
11 DNA Microarray Demand 166
12 Other DNA Testing Material Demand by Type 167
13 Nanotechnology In Vivo Diagnostic Product Demand 179

SECTION VII -- NANOTECH MEDICAL SUPPLIES
& DEVICES
1 Nanotechnology Medical Supply & Device Demand
by Product Group 188
2 Nanotechnology Orthopedic Product Demand 190
3 Nanopolymer Bone Cement Demand 191
4 Nanomaterial Bone Substitute Demand 194
5 Nanotechnology Orthopedic Implant Demand by Type 197
6 Nanotechnology Wound Management Product Demand 198
7 Nanotechnology Wound Closure Demand 200
8 Nanotechnology Wound Dressing Demand 203
9 Nanotechnology Dental Product Demand 206
10 Nanotechnology Surgical Product Demand 208
11 Nanotechnology Ophthalmic Product Demand 209
12 Other Nanotechnology Medical Supply & Device Demand 212

SECTION VIII -- APPLICATIONS
1 Nanotechnology Medical Product Demand by Application 222
2 Nanotechnology Cancer Product Demand 223
3 Nanotechnology Central Nervous System Product Demand 230

(continued on next page) 4 Nanotechnology Product Demand for Infective & Parasitic
Conditions 236
5 Nanotechnology Cardiovascular Product Demand 240
6 Nanotechnology Medical Product Demand in Other
Applications by Product Class & Type 246

SECTION IX -- INDUSTRY STRUCTURE
1 Selected Cooperative Agreements 258

LIST OF CHARTS

CHART NUMBER PAGE

SECTION III -- NANOTECHNOLOGY OVERVIEW
1 Nanotechnology Medical Product Demand by Type, 2011 46

SECTION V -- NANOMEDICINES
1 Nanomedicine Demand by Therapeutic Class, 2011 74
2 Nanomedicine Demand by Product Group, 2011 76

SECTION VI -- NANODIAGNOSTICS
1 Nanodiagnostics Demand by Product Group, 2011 142

SECTION VII -- NANOTECH MEDICAL SUPPLIES
& DEVICES
1 Nanotech Medical Supply & Device Demand by Product
Group, 2011 189

SECTION VIII -- APPLICATIONS
1 Nanotechnology Medical Product Demand by
Application, 2011 222

SECTION IX -- INDUSTRY STRUCTURE
1 Nanotechnology Medical Product Market Share, 2006 254

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